Pure Encapsulations - Rapid Calm, 30 caps
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- Australia Post Standard Delivery (2-6 business days): $11
- Australia Post Express Delivery (1-3 business days): $16
This formula is ideal for as-needed relief from occasional everyday stressors.*
Description
- Helps to moderate general feelings of stress and occasional anxiety*
- Provides vitamin B6, a cofactor in the biosynthesis of serotonin*
- Contains clinically studied Zembrin®
- Contains Suntheanine®, a clinically studied L-theanine
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent
Zembrin® reduces occasional anxiety*. In a randomized, placebo-controlled clinical trial, a single dose of 25 mg Zembrin® 30 minutes before a simulated public speaking task reduced perceived anxiety level and its physical symptoms, such as elevated heart rate in healthy volunteers.¹
L-theanine (Suntheanine®) reduced stress-related symptoms and supported sleep quality in healthy adults.
In a double-blind crossover trial, 30 healthy adults received l-theanine (200 mg Suntheanine®/day) or placebo for 4 weeks. L-theanine significantly improved stress-related symptoms, including low-mood symptoms and occasional anxiety per validated questionnaires and sleep (Pittsburgh Sleep Quality Index; PSQI) scores compared to placebo.⁵
MECHANISMS OF ACTION
The mechanism of action of Zembrin® remains unclear.
In vitro, Zembrin® and its principal alkaloids, mesembrine and mesembrenone, inhibited the serotonin reuptake transporter.⁴ This action may prolong the effects of serotonin, a neurotransmitter with mood-elevating effects.
Vitamin B6 is a cofactor for aromatic amino acid decarboxylase (AADC), a key enzyme in serotonin production.
This enzyme uses pyridoxal 5'-phosphate (activated vitamin B6) to convert 5-HTP to serotonin.⁵
Zembrin® reduced activity of the amygdala and its associated circuitry within 2 hours of administration.
In a randomized clinical trial, a single 25 mg dose of Zembrin® moderated fear responsivity and activation of the brain's amygdala, assessed using functional Magnetic Resonance Imaging (fMRI) technology.² The amygdala is a part of the brain that perceives threats and dictates behavior in stressful situations.
References
1. Reay J, Wetherell MA, Morton E. Hum Psychopharmacol. 2020 Nov;35(6):1-7.
2. Terburg D, Syal S, Rosenberger LA, et al. Neuropsychopharmacology. 2013 Dec;38(13):2708-16.
3. Hidese S, Ogawa S, Ota M, et al. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362.
4. Harvey AL, Young LC, Viljoen AM, Gericke NP. J Ethnopharmacol. 2011 Oct 11;137(3):1124-9.
5. Blau N, Pearson TS, Kurian MA, et al. 2023 Oct 12. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.
6. Anas Sohail A, et al. Cureus. 2021 Dec 30;13(12):e20828.
7. Nathan PJ, et al. J Herb Pharmacother. 2006;6(2):21-30.
8. Lardner AL. Nutr Neurosci. 2014 Jul;17(4):145-55.
9. Sebih F, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1724-1734.
Ages 18 and up
May assist with:
Support for occasional anxiety in less than one hour‡
Support for occasional stress‡
As a dietary supplement, take 1 capsule as needed, with or between meals, or as directed by a health professional.
Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach out children.
Store in a cool, dry place below 25ºC.
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