Enzyme Science, (PEA)+ - Pain Relief and Stress Support Supplement

Palmitoylethanolamide (PEA) is an extensively researched natural ingredient for important neuroprotective actions.*4

This ingredient has been utilized for decades and is available in dietary supplements worldwide as an option for the onset of physiological stress.*

PEA is an endogenous fatty acid amide that belongs to the family of biologically active lipids that are increased by the body to soothe discomfort naturally.*5

PEA was identified over 60 years ago when it was isolated from extracts of brain, liver, and muscle of rat and guinea pig. It was later found to be contained in chicken egg yolk, olive oil, sa ower and soy lecithin, peanut meal, and several other foods.

Traditionally, PEA as a lipid in its unprocessed state has a large particle size which limits its solubility and bioavailability. This (PEA)+ uses an air-jet milled, ultra-micronized form, which reduces its particle size, thus increasing purity. Research has shown that, in animal studies, this form of PEA has a “superior” action.6,7

The biological properties and mechanisms of PEA naturally produced by the body, involve a variety of effects including those upon glial and mast cells, cannabinoid-2 receptors, NF-kB, and effects on the nuclear receptor peroxisome proliferator-activated receptors (PPARs).8 Glial and mast cells naturally play a key role in the body’s management of discomfort. Cannabinoid-2 receptors are more often found on immune cells, in the gastrointestinal tract, and in the peripheral nervous system. In addition, PEA enhances the effects of the fatty acid anandamide (also referred to as the “bliss molecule”) when it binds to CB receptors.*

Meriva® Phytosome is a patented formulation of curcumin made with sunflower-derived phosphatidylcholine. Phytosome® technology improves the bioavailability by o ering a higher stability and oral absorption in comparison with unformulated curcumin.9

References:

4. Scuderi C, Bronzuoli MR, Facchinetti R, et al. Transl Psychiatry. 2018 Jan 31;8(1):32. doi: 10.1038/s41398-017-0076-4.

5. Gabrielsson L, Mattsson S, Fowler CJ. Br J Clin Pharmacol. 2016;82(4):932-42.

6. Impellizzeri, D., Bruschetta, G., Cordaro, M., Crupi, R., Siracusa, R., Esposito, E., & Cuzzocrea, S. (2014). Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain. Journal of neuroinflammation, 11, 136. https://doi.org/10.1186/s12974-014-0136-0

7. Boccella S, Cristiano C, Romano R, et al. Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway. Neurobiol Dis. 2018 Sep 25;121:106-119.

8. Petrosino S, Di Marzo V. Br J Pharmacol. 2017 Jun;174(11):1349-1365. doi: 10.1111/bph.13580. Epub 2016 Sep 29. Review.

9. John Cuomo, Giovanni Appendino, Adam S. Dern, Erik Schneider, Toni P. McKinnon, Mark J. Brown, Stefano Togni, and Brian M. Dixon. Journal of Natural Products. 2011 74 (4), 664-669. 74 (4), 664-669.3

Adult use: Take 2 capsules twice daily, with or without food. Consult with physician prior to use if you are pregnant or nursing, taking medications or have a medical condition.

Consult with your physician before using this product if you are pregnant, nursing or taking medications.

Always read the label and use as directed. If symptoms persist see your healthcare practitioner.

Do not take if tamper-evident seal is broken or missing.

Keep out of the reach of children.

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